The National Magnetic Resonance Facility at Madison (NMRFAM) is a state of the art NMR spectrometer facility located in the Department of Biochemistry at the University of Wisconsin-Madison. NMRFAM equipment and resources are available to ALL scientists both within and outside of the university. Our experienced staff is available to train users as well as provide consultation and collaboration on experimental design, data collection and analysis. Funding comes from the NIH NIGMS-supported P41 Biomedical Technology Research Centers (BTRC) and from user fees.
Technology Research & Development (TR&D) The research emphasis at NMRFAM are the important areas of:(1) fast data collection and automated data analysis of biomacromolecules (2) technology for larger proteins, nucleic acids, and complexes (3) investigations of metal-containing (paramagnetic) proteins (4) dynamics of macromolecules (5) structure-function investigation of RNA molecules and their complexes with metal ions and proteins (6) metabolomics and natural products
NMR instrumentation [400,500(2),600(4),750,800,900 MHz] – mixture of 4 Agilent/Varian and 6 Bruker spectrometers (cryogenic probes on all but 400) (2) HPLC-SolidPhaseExtraction-liquid handling for 1.7 and 5mm NMR tubes with integrated MicrOTOF Mass spectrometer (3) Bruker AXS Nanostar SAXS (small angle X-ray scattering) (4) external access to processing and analysis servers, metabolomics database, software packages, and pulse program libraries (5) consultation with current and potential users workshops (3) new software tools pulse programs and software, (2) newsletter and website, (3) publications, lectures, posters, workshops, and personnel exchanges, (4) collaborations with other facilities in the US and abroad