Biochem 800 – Practical Nuclear Magnetic Resonance Theory
Biochem 800:
Practical Nuclear
Magnetic
Resonance Theory
The lecture notes are available as AcrobatReader PDF files.
The class is held in Biochem 3311.
Scope of the course: study of multipulsed, multinuclear, and
multidimensional NMR spectroscopy; emphasis on the vector and product
operator
formalisms for the analysis of modern pulse sequences.
Course format: (2 credits) lecture and
discussion;
grades to be based on participation and problem sets.
Topics to be covered:
The Vector Paradigm
Coherence and Magnetization
Radio Frequency (Rf) Excitation
Chemical Shifts
Signal Detection
Fourier Transformation
Coherence Transfer Pathways and Phase Cycling
Pulsed Field Gradients
Scalar Coupling
Product Operator Formalism
Coherence Transfer
Isotope Directed Editing
Two-Dimensional NMR
Multi (>2)-Dimensional NMR
1H, 13C, and 15N Triple Resonance 3d and 4d NMR
Pulse Concatenation and Sequence Optimization
Relaxation
Prerequisites: introductory NMR (e.g. organic
chemistry),
basic trigonometry, elementary physics, and physical chemistry.
Course materials: lecture notes and literature articles