Amalia Muñoz, Ph.D.

Associate Researcher

BioMagResBank and Markley's Lab

Publications

1. "Estudio comparativo de las caracteristicas analiticas de las (Cadmio,zinc)-tioneinas y moleculas organicas intrinsecas a su estructura". A. Muñoz, Ph.D. Dissertation, Facultad de Farmacia, Universidad Complutense, Madrid, Spain. (1992).
2. "Molecular heterogeneity of the pancreatic islet metallothionein", B. Ribas, A. Muñoz, J.P. Camblor, R. Gomis, Y. Sarri. In: Trace Element Anal. Chem. Med. Biol. vol. 6, Walter de Grunter Co., Berlin-New York, 437-443 (1993).
3. "Spectrophotometric Study on Metallothionein and Related Molecules”", A. Muñoz, J. Calved and A.R. Rodriguez, Quimica Analitica, 14: 36-44 (1995).
4. "Quantitative Determination of Cd,Zn Thioneins Using Differential Pulse Polarography", A. Munoz, A. R. Rodriguez, Analyst, 120: 529-532 (1995).
5. "Reaction of ¹¹¹Cd₇Metallothionein with EDTA: A Reappraisal", T. Gan, A. Muñoz, C.F. Shaw III and D.H. Petering, J. Biol. Chem., 270: 5339-5345 (1995).
6. "Electrochemical Behaviour of Metallothioneins and Related Molecules. I. Lys-Cys-Thr-Cys-Cys-Ala Thionein Fragment [56-61] MT I", J. Mendieta, J. Chivot, A. Muñoz and A.R. Rodriguez, Electroanal., 7: 663-669 (1995).
7. "Electrochemical Behaviour of Metallothioneins and Related Molecules. II. Lys-Cys-Thr-Cys-Cys-Ala Thionein Fragment [56-61] MT I in presence of Cadmium and/or Zinc", A. Muñoz, A.R. Rodriguez, Electroanal., 7: 670-673 (1995).
8. "Electrochemical Behaviour of Metallothioneins and Related Molecules. III. Metallothionein", A. Muñoz, A. R. Rodriguez, Electroanal., 7: 674-680 (1995).
9. "Stoichiometry and cluster Specificity of copper binding to Metallothionein. Homogeneous Metal Clusters", P. Chen, A. Muñoz, D. Nettesheim, C.F. Shaw III and D.H. Petering, Biochem. J., 317: 395-402 (1996).
10. "Kinetic Studies of the Alkylation and Subsequent Metal Release from Metallothionein by the Electrophile N-Ethylmaleimide", C.F. Shaw III, L. He, A. Muñoz, M.M. Savas, S. Chi, C.L. Fink, G. Tong and D.H. Petering, J. Biological Inorganic Chemistry, 2: 65-73 (1997).
11. "Synthetic Peptides and Domains of Metallothionein for Structure Function Studies: Rabbit Liver MT-IIA Peptide 49-61 and Lobster MT ß_N, ß_C and ß_C-N" A. Muñoz, F. Laib, E. DeRose, D.H. Petering, J. Ejnik and C.F. Shaw III, Metallothionein IV, Klasassen, C.D. ed. Basel - Boston - Berlin - Birkhauser, pp. 99-109 (1999).
12. "Cellular Metallothionein: Properties of Apometallothionein and the Comparative Toxicity of Cd²⁺ and Cd-metallothionein", D.H. Petering, M. Dughish, M. Huang, S. Krezoski, S. Krull, D. Lewand, A. Muñoz, L. Ren, S. Venkatesh, S. Blumenthal and C.F. Shaw III. Metallothionein IV, Klasassen, C.D. ed. Basel - Boston - Berlin - Birkhauser, pp. 459-466 (1999).
13. "Characterization of the Cadmium complex of the Peptide 49-61. A Putative Nucleation Center for Cadmium-induced Folding in Rabbit Liver Metallothionein-IIA". A. Muñoz, F. Laib, D.H. Petering and C.F. Shaw III, J. Biological Inorganic Chemistry, 4: 495-507 (1999).
14. "Interprotein Metal Ion Exchange between Cadmium Carbonic Anhydrase and Apo or Zinc-metallothionein". J. Ejnik, A. Muñoz, T. Gan, C. F. Shaw III and D.H. Petering. J. Biological Inorganic Chemistry, 6: 784-790(1999).
15. "Reactions of Electrophilic Reagents That Target the Thiolate Groups of Metallothionein Clusters: Preferential reaction of the alpha-domain with 5,5'-dithio-bis(2-nitrobenzoate) (DTNB) and Aurothiomalate (AuSTM)" A. Muñoz, D.H. Petering and C.F. Shaw III. Inorganic Chemistry, 25: 5655-5659, (1999).
16. "Structure-Reactivity Relationships among Metallothionein Three-metal Domains: Role of Non-Cysteine Amino Acid Residues in Lobster-metallothionein and Human-metallothionein-3". A. Muñoz, D.H. Petering and C.F. Shaw III, Accepted in: Inorg. Chem., (1999).
17. "Requirements for stable Metallothionein Clusters Examined Using Synthetic Lobster Domains". A. Muñoz, D.H. Petering and C.F. Shaw III, Accepted in: Mar. Environ. Res. Soc. (1999.).

Papers in preparation

1. "EDTA Reaction for rabbit liver Zn₇MT and lobster Cd₆MT. Comparison to the reaction with rabbit liver Cd₇MT". A. Muñoz, J. Schultz, C.F. Shaw III and D.H. Petering, In preparation.
2. "Three-Dimensional Solution Structure of Isolated Alpha-MT2 From Rabbit Determined by Homonuclear and Heteronuclear Magnetic Resonance Spectroscopy". J. Ejnik, A. Muñoz, E. DeRose, C. F. Shaw III and D.H. Petering, In preparation.
3. "Determination of the solution three dimensional structure of chemically-synthesized native ¹¹³Cd₃ß_C domain of Lobster Metallothionein by NMR spectroscopy". A. Muñoz, F.H. Försterling, C.F. Shaw III, D.H. Petering. In preparation.
4. "Determination of the solution structure and H^N-S hydrogen bonding in the chemically synthesized native ¹¹³Cd₃ß_Ndomain of Lobster Metallothionein using NMR spectroscopy". A. Muñoz, F.H. Försterling, D.H. Petering. In preparation.
5. "On why the Phe82Met/Met80His and Phe82Met/Met80Ala variants of Yeast Iso-1-Cytochrome c don't undergo redox driven changes in axial coordination", B.A. Feinberg, A. Muñoz, X. Liu, L.A. Petro, A. Schejter, E. Margoliash. In preparation.
6. "Thiol-disulfide Interchange Between Zn-Metallothioneins and DTNB, a Model Reagent for Oxidized Glutathione". A. Muñoz, C.F. Shaw III, D.H. Petering. In preparation.
7. "Copper Stoichiometry in Mammalian and Lobster Metallothioneins". A. Muñoz, M. Dughish, Z. Zhu, C.F. Shaw III and D.H. Petering, In preparation.
8. "Kinetic Studies of Zn₇MT with chrysotherapic agents and related gold complexes". A. Muñoz, D.H. Petering and C.F. Shaw III, In preparation.